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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ITGAM-cre)2781Gkl
transgene insertion 2781, George Kollias
MGI:3629092
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:5444201
cn2
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
involves: C57BL/6 * CBA MGI:3629233
cn3
Ptger2tm1.1Kand/Ptger2tm1.1Kand
Tg(ITGAM-cre)2781Gkl/0
involves: C57BL/6 * CBA MGI:5559329


Genotype
MGI:5444201
cn1
Allelic
Composition
Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grntm1Far mutation (1 available); any Grn mutation (32 available)
Tg(ITGAM-cre)2781Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in MPTP-treated mice
• greater in mice treated with MPTP compared with control mice

homeostasis/metabolism

cellular

hematopoietic system
• in MPTP-treated mice

immune system
• in MPTP-treated mice




Genotype
MGI:3629233
cn2
Allelic
Composition
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ITGAM-cre)2781Gkl mutation (1 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
amyotrophic lateral sclerosis type 1 DOID:0060193 OMIM:105400
J:109131




Genotype
MGI:5559329
cn3
Allelic
Composition
Ptger2tm1.1Kand/Ptger2tm1.1Kand
Tg(ITGAM-cre)2781Gkl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1.1Kand mutation (0 available); any Ptger2 mutation (20 available)
Tg(ITGAM-cre)2781Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia
• expression analysis indicates a blunted systemic and brain innate immune response to systemic LPS treatment

homeostasis/metabolism
• decrease in the inflammatory response and microglial and astrocyte activation after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in the substantia nigra pars compacta
• however, no rescue of the loss of TH+ neurons in MPTP treated mice is detected
• increase in dopamine turnover in MPTP treated mutants compared to similarly treated controls

nervous system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

hematopoietic system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia





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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory