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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(ITGAM-cre)2781Gkl
transgene insertion 2781, George Kollias
MGI:3629092
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N MGI:5444201
cn2
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
involves: C57BL/6 * CBA MGI:3629233
cn3
Ptger2tm1.1Kand/Ptger2tm1.1Kand
Tg(ITGAM-cre)2781Gkl/0
involves: C57BL/6 * CBA MGI:5559329


Genotype
MGI:5444201
cn1
Allelic
Composition
Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grntm1Far mutation (1 available); any Grn mutation (16 available)
Tg(ITGAM-cre)2781Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in MPTP-treated mice
• greater in mice treated with MPTP compared with control mice

homeostasis/metabolism

cellular

hematopoietic system
• in MPTP-treated mice

immune system
• in MPTP-treated mice




Genotype
MGI:3629233
cn2
Allelic
Composition
Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(ITGAM-cre)2781Gkl mutation (1 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131




Genotype
MGI:5559329
cn3
Allelic
Composition
Ptger2tm1.1Kand/Ptger2tm1.1Kand
Tg(ITGAM-cre)2781Gkl/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptger2tm1.1Kand mutation (0 available); any Ptger2 mutation (13 available)
Tg(ITGAM-cre)2781Gkl mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia
• expression analysis indicates a blunted systemic and brain innate immune response to systemic LPS treatment

homeostasis/metabolism
• decrease in the inflammatory response and microglial and astrocyte activation after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in the substantia nigra pars compacta
• however, no rescue of the loss of TH+ neurons in MPTP treated mice is detected
• increase in dopamine turnover in MPTP treated mutants compared to similarly treated controls

nervous system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

hematopoietic system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory