Mouse Genome Informatics
cn1
    Grntm1Far/Grntm1Far
Tg(ITGAM-cre)2781Gkl/0

involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• in MPTP-treated mice
• greater in mice treated with MPTP compared with control mice

homeostasis/metabolism

cellular

hematopoietic system
• in MPTP-treated mice

immune system
• in MPTP-treated mice


Mouse Genome Informatics
cn2
    Tg(ITGAM-cre)2781Gkl/0
Tg(SOD1*G37R)1Dwc/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• expression of Cre in microglia extends the lifespan of mutant SOD1-expressing mice by an average of 99 days compared to non-ITGAM-cre expressing mice

nervous system
• progression of later stage disease is slowed by an average of 75 days in mice expressing both transgenes

Mouse Models of Human Disease
OMIM IDRef(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131


Mouse Genome Informatics
cn3
    Ptger2tm1.1Kand/Ptger2tm1.1Kand
Tg(ITGAM-cre)2781Gkl/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia
• expression analysis indicates a blunted systemic and brain innate immune response to systemic LPS treatment

homeostasis/metabolism
• decrease in the inflammatory response and microglial and astrocyte activation after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in the substantia nigra pars compacta
• however, no rescue of the loss of TH+ neurons in MPTP treated mice is detected
• increase in dopamine turnover in MPTP treated mutants compared to similarly treated controls

nervous system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

hematopoietic system
• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia