Phenotypes associated with this allele

• Allele Symbol: H2^h2
• Allele Name: h2 variant
• Allele ID: MGI:3628768
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2^h2/H2^h2	NOD.Cg-H2^h2	MGI:3628772
ht2	H2^h2/H2^g7	NOD.Cg-H2^h2	MGI:3628788

Genotype
MGI:3628772

hm1

• Allelic Composition: H2^h2/H2^h2
• Genetic Background: NOD.Cg-H2^h2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:14178 )

• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections

endocrine/exocrine glands

insulitis ( J:14178 )

• female mice develop insulitis by 9 months of age without cyclophosphamide treatment

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system

insulitis ( J:14178 )

• female mice develop insulitis by 9 months of age without cyclophosphamide treatment

periinsulitis ( J:14178 )

• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 9 months of age; mice between 10 and 12 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no female mice homozygous for the haplotype develop diabetes spontaneously

Genotype
MGI:3628788

ht2

• Allelic Composition: H2^h2/H2^g7
• Genetic Background: NOD.Cg-H2^h2

immune system

decreased susceptibility to autoimmune diabetes ( J:14178 )

• no females develop diabetes spontaneously over 5-7 months