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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rasgrp3tm1Jstn
targeted mutation 1, James C Stone
MGI:3625862
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rasgrp3tm1Jstn/Rasgrp3tm1Jstn involves: 129P3/J * C57BL/6J MGI:3629772
cx2
 		Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Rasgrp3tm1Jstn/Rasgrp3tm1Jstn 		involves: 129P3/J * C57BL/6J MGI:3629773


Genotype
MGI:3629772
hm1
Allelic
Composition		 Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic
Background		 involves: 129P3/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp3tm1Jstn mutation (1 available); any Rasgrp3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is defective compared to wild-type
• stimulation anti-IgM or co-stimulation with anti-IgM and anti-CD40 produces less proliferation than that seen in wild-type or Rasgrp1-deficient cultures
abnormal humoral immune response ( J:108677 )
• in both T-cell dependent and independent responses, mice produced weaker responses than wild-type
decreased IgG level ( J:108677 )
• mice exhibit lower titers of IgG1 and IgG2a in their sera compared to wild-type

hematopoietic system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is defective compared to wild-type
• stimulation anti-IgM or co-stimulation with anti-IgM and anti-CD40 produces less proliferation than that seen in wild-type or Rasgrp1-deficient cultures
decreased IgG level ( J:108677 )
• mice exhibit lower titers of IgG1 and IgG2a in their sera compared to wild-type




Genotype
MGI:3629773
cx2
Allelic
Composition		 Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Rasgrp3tm1Jstn/Rasgrp3tm1Jstn
Genetic
Background		 involves: 129P3/J * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasgrp1tm1Jstn mutation (1 available); any Rasgrp1 mutation (55 available)
Rasgrp3tm1Jstn mutation (1 available); any Rasgrp3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is lower than in wild-type or either single mutant
• B cells show weak proliferation when co-stimulated by anti-IgM and anti-CD40 compared to wild-type or either single mutant while response to anti-IgM, proliferative response to is weaker than wild-type or Rasgrp1-deficient mice
decreased plasma cell number ( J:108677 )
• mice have a lower proportion of CD138+ cells at 6 weeks compared to Rasgrp1-deficient mice
abnormal humoral immune response ( J:108677 )
• in T-cell independent responses, mice showed the greatest defect in T cell-dependent type I induction of IgG1 and IgG2a
• mice also show defective response in T cell-dependent response assays compared to wild-type

hematopoietic system
decreased B cell number ( J:108677 )
• during in vitro assays where B cells from young mice are co-stimulated with Il4 and anti-IgM, proliferation is lower than in wild-type or either single mutant
• B cells show weak proliferation when co-stimulated by anti-IgM and anti-CD40 compared to wild-type or either single mutant while response to anti-IgM, proliferative response to is weaker than wild-type or Rasgrp1-deficient mice
decreased plasma cell number ( J:108677 )
• mice have a lower proportion of CD138+ cells at 6 weeks compared to Rasgrp1-deficient mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory