Phenotypes associated with this allele

• Allele Symbol: Trpa1^tm1Kykw
• Allele Name: targeted mutation 1, Kelvin Y Kwan
• Allele ID: MGI:3624810
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpa1^tm1Kykw/Trpa1^tm1Kykw	involves: 129P2/OlaHsd * C57BL/6J	MGI:3625358

Genotype
MGI:3625358

hm1

• Allelic Composition: Trpa1^tm1Kykw/Trpa1^tm1Kykw
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hyporesponsive to tactile stimuli ( J:108343 )

• homozygous mutants are less sensitive to punctate mechanical stimuli relative to littermates; fewer mutants show a pain response than wild-type and the average threshold is higher in mutants

• 2 hours after injection with bradykinin, the threshold for mechanical sensitivity is unchanged in mutants while it is reduce 5-fold in wild-type

abnormal thermosensation ( J:108343 )

• mutants show reduced sensitivity to the cooling sensation elicited by a drop of acetone on the hindpaw compared with wild-type and heterozygotes: differences between wild-type and mutants is greater for females than males

increased thermal nociceptive threshold ( J:108343 )

hearing/vestibular/ear

decreased threshold for auditory brainstem response ( J:108343 )

• at frequency of 32kHz in an ABR test, mutant mice are more sensitive than wild-type, however, results are similar to controls at all other frequencies tested

• hearing and vestibular function are normal as assesed by behavioral tests

• whole-cell transduction currents in mouse utricular hair cells are similar to controls

taste/olfaction

abnormal taste sensitivity ( J:108343 )

• knockout mice consume more mustard oil-containing water than wild-type or heterozygotes; at the highest concentration, mutants consume more than one third of the normal amount