About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trpa1tm1Kykw
targeted mutation 1, Kelvin Y Kwan
MGI:3624810
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trpa1tm1Kykw/Trpa1tm1Kykw involves: 129P2/OlaHsd * C57BL/6J MGI:3625358


Genotype
MGI:3625358
hm1
Allelic
Composition
Trpa1tm1Kykw/Trpa1tm1Kykw
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trpa1tm1Kykw mutation (1 available); any Trpa1 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• homozygous mutants are less sensitive to punctate mechanical stimuli relative to littermates; fewer mutants show a pain response than wild-type and the average threshold is higher in mutants
• 2 hours after injection with bradykinin, the threshold for mechanical sensitivity is unchanged in mutants while it is reduce 5-fold in wild-type
• mutants show reduced sensitivity to the cooling sensation elicited by a drop of acetone on the hindpaw compared with wild-type and heterozygotes: differences between wild-type and mutants is greater for females than males

hearing/vestibular/ear
• at frequency of 32kHz in an ABR test, mutant mice are more sensitive than wild-type, however, results are similar to controls at all other frequencies tested
• hearing and vestibular function are normal as assesed by behavioral tests
• whole-cell transduction currents in mouse utricular hair cells are similar to controls

taste/olfaction
• knockout mice consume more mustard oil-containing water than wild-type or heterozygotes; at the highest concentration, mutants consume more than one third of the normal amount





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory