Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation
(2 available);
any
Coch mutation
(42 available)
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hearing/vestibular/ear
N |
• despite hearing and vestibular deficits, no gross abnormalities are seen in the cochlear duct or its accessory structures
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• increased threshold or absent at the highest frequency test (41.2 Hz) at 21 months of age
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• increase in VsEP thresholds at 13 and 21 months of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation
(2 available);
any
Coch mutation
(42 available)
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normal phenotype
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• surprisingly, homozygotes are viable and overtly normal and females display no defects in implantation or reproduction relative to wild-type littermates
(J:105566)
• at ~5 months, homozygotes do not display any apparent inner ear histopathology or any significant hearing loss relative to wild-type mice
(J:108251)
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation
(2 available);
any
Coch mutation
(42 available)
|
|
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hearing/vestibular/ear
N |
• at P19, 3- and 5- months of age, homozygotes exhibit no significant differences in auditory brainstem responses to click and pure-tone stimuli (8, 16, 32 kHz) relative to wild-type mice
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cochtm1.1Stw mutation
(2 available);
any
Coch mutation
(42 available)
|
|
|
hearing/vestibular/ear
N |
• unlike in homozygous mutant mice, no hearing deficit is detected at any age
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• increase in VsEP thresholds at 21 months of age
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