All Phenotypes Espl1<tm1.2Kna> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Espl1^tm1.2Kna
targeted mutation 1.2, Kim Nasmyth
MGI:3624201

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Espl1^tm1.2Kna/Espl1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625273
cn2	Espl1^tm1.1Kna/Espl1^tm1.2Kna Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL	MGI:5551815
cx3	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna	involves: 129P2/OlaHsd * C57BL/6	MGI:3625275

Allelic Composition	Espl1^tm1.2Kna/Espl1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:107916 )

• die before E6.5

Allelic Composition	Espl1^tm1.1Kna/Espl1^tm1.2Kna Wapl^tm1.1Jmpt/Wapl^tm1.2Jmpt Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (942 available)
Wapl^tm1.1Jmpt mutation (0 available); any Wapl mutation (168 available)
Wapl^tm1.2Jmpt mutation (0 available); any Wapl mutation (168 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:205429 )

• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells

Allelic Composition	Espl1^tm1.2Kna/Espl1⁺ Pttg1^tm1.2Kna/Pttg1^tm1.2Kna
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1^tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Pttg1^tm1.2Kna mutation (0 available); any Pttg1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:107916 )

• die at E11.5

cellular

abnormal cell nucleus morphology ( J:107916 )

• at E9.5 larger, lobed nuclei are seen in several organs, including the somites, heart, and brain

• after 10 days in culture MEFs have large lobed nuclei

abnormal mitosis ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles and 8 were undergoing anaphase with lagging chromosomes

abnormal mitotic spindle morphology ( J:107916 )

• 16 of 24 mitotic MEF cells had multipolar spindles

abnormal cell death ( J:107916 )

• extensive cell death is seen at E9.5

embryo

decreased embryo size ( J:107916 )

• at E10.5

abnormal neural tube morphology ( J:107916 )

• at E10.5

abnormal somite development ( J:107916 )

• irregular somites are seen at E10.5

nervous system

abnormal neural tube morphology ( J:107916 )

• at E10.5

growth/size/body

decreased embryo size ( J:107916 )

• at E10.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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