Phenotypes associated with this allele

• Allele Symbol: Lsr^tm1Mdar
• Allele Name: targeted mutation 1, Michel Darmon
• Allele ID: MGI:3623628
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lsr^tm1Mdar/Lsr^tm1Mdar	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * MF1)	MGI:3623798

Genotype
MGI:3623798

hm1

• Allelic Composition: Lsr^tm1Mdar/Lsr^tm1Mdar
• Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * MF1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:92354 )

• die by E15.5

• crosses of F1 heterozygotes or chimeras to F1 heterozygotes produced 3 live adult males however no survivors were produced from F2 or later crosses and no difference in survival was seen on the different strain backgrounds

liver/biliary system

liver hypoplasia ( J:92354 )

• at E14.5 liver size and cell density are reduced and in some cases the liver is reduced to a punctiform red spot

cardiovascular system

hemorrhage ( J:92354 )

• at E14.5, some homozygous embryos display superficial hemorrhages

growth/size/body

decreased fetal size ( J:92354 )

• smaller size at E14.5 but overall development appears similar to control littermates

reproductive system

male infertility ( J:92354 )

♂

integument

pallor ( J:92354 )

• at E14.5, some homozygous embryos appear whiter than control littermates

abnormal skin condition ( J:92354 )

• at E14.5, some homozygous embryos display superficial detachment of the skin