Phenotypes associated with this allele

• Allele Symbol: Avpr1a^tm1Gzt
• Allele Name: targeted mutation 1, Gozoh Tsujimoto
• Allele ID: MGI:3623418
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Avpr1a^tm1Gzt/Avpr1a^tm1Gzt	involves: 129 * C57BL/6J	MGI:3665424

Genotype
MGI:3665424

hm1

• Allelic Composition: Avpr1a^tm1Gzt/Avpr1a^tm1Gzt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

poor circulation ( J:110099 )

• homozygotes exhibit a significant 9% reduction in circulating blood volume, although total body weight, hematocrit values, and red blood cell counts remain normal

abnormal heart rate ( J:110099 )

• homozygotes display normal baseline heart rates relative to wild-type mice

• however, the bradycardiac response to electrical stimulation of the vagus nerve is significantly attenuated, indicating a CNS defect

hypotension ( J:110099 )

• under basal conditions, homozygotes exhibit significantly reduced systolic, diastolic and mean arterial pressures relative to wild-type mice

• however, no significant changes in heart rate, heart size and histology, blood chemistry, blood cell counts, cardiac output or renal function are observed

abnormal vasoconstriction ( J:110099 )

• homozygotes show complete absence of AVP-induced vasopressor responses; instead, AVP causes a decrease in blood pressure, partly through V2 receptor-mediated release of nitric oxide from the vascular endothelium

nervous system

abnormal baroreceptor physiology ( J:110099 )

• homozygotes display significantly impaired arterial baroreceptor reflexes

homeostasis/metabolism

decreased circulating atrial natriuretic factor ( J:110099 )

• homozygotes exhibit significantly reduced baseline atrial natriuretic peptide levels relative to wild-type mice

abnormal circulating corticosterone level ( J:110099 )

• responses to vasoactive hormones including AVP remain mostly intact; however, the ACTH-stimulated corticosterone response is significantly reduced

• homozygotes display normal baseline corticosterone levels relative to wild-type mice

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:110099 )

• homozygotes show abnormal adrenal gland histology, with unclear adrenocortical zonation and enhanced depositions of lipofuscin in the reticular layer

muscle

abnormal vasoconstriction ( J:110099 )

• homozygotes show complete absence of AVP-induced vasopressor responses; instead, AVP causes a decrease in blood pressure, partly through V2 receptor-mediated release of nitric oxide from the vascular endothelium

behavior/neurological

abnormal long-term spatial reference memory ( J:107607 )

• homozygotes display impaired spatial memory in an eight-arm radial maze task, with an increase in the number of errors after several days of training sessions compared to controls