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Allele Symbol Allele Name Allele ID |
Emdtm1.1Stw targeted mutation 1.1, Colin L Stewart MGI:3621266 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• no signs of muscular atrophy or dystrophy or cardiac pathology up to 1 year of age
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N |
• nuclear morphology was normal and other nuclear envelop proteins are normally distributed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• increase in number of small and reduction in number of large cardiomyocytes
• increase of mononucleated and a decrease of multinucleated cardiomyocytes
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• reduction in size of cardiomyocytes
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• increase in the number of cardiomyocytes in 5 week old hearts
• however, size and left ventricular mass of hearts is normal
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• slight, but significant, increase in heart weight to tibia length ratio
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• increase in levels of cardiac stress markers ANP and BNP
• however, no cardiac fibrosis is seen
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• lower ejection fraction of both the right and left ventricles
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• increase in end-diastolic and end-systolic volumes in mice and lower ejection fraction of both the right and left ventricles
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• mice exhibit a decline of ejection fraction and increase of end-systolic volume 3- and 6- months after transverse aortic constriction (TAC) indicating impaired response to pressure overload
• marker analysis indicates increased cardiac remodeling in hearts after TAC
• however, no effect on left ventricular mass after TAC is seen
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• mice exhibit a decline of ejection fraction and increase of end-systolic volume 3- and 6- months after transverse aortic constriction (TAC) indicating impaired response to pressure overload
• marker analysis indicates increased cardiac remodeling in hearts after TAC
• however, no effect on left ventricular mass after TAC is seen
|
|
|
• increase in number of small and reduction in number of large cardiomyocytes
• increase of mononucleated and a decrease of multinucleated cardiomyocytes
|
|
|
• reduction in size of cardiomyocytes
|
|
|
• increase in the number of cardiomyocytes in 5 week old hearts
• however, size and left ventricular mass of hearts is normal
|
|
|
• lower ejection fraction of both the right and left ventricles
|
|
|
• slight, but significant, increase in heart weight to tibia length ratio
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
|
• after muscle degeneration resulting from cardiotoxin injection,myofiber regeneration is slower
• smaller diameter at 7 days, similar to 3 day controls
• fiber diameter more heterogeneous
• 14 day animals similar to controls except for increased variability in fiber diameter
• delayed differentiation of myoblasts in culture
• no signs of muscular atrophy or dystrophy or cardiac pathology up to 1 year of age
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|
N |
• nuclear morphology was normal and other nuclear envelop proteins are normally distributed
|
|
|
• after muscle degeneration resulting from cardiotoxin injection,myofiber regeneration is slower
• smaller diameter at 7 days, similar to 3 day controls
• fiber diameter more heterogeneous
• 14 day animals similar to controls except for increased variability in fiber diameter
• delayed differentiation of myoblasts in culture
• no signs of muscular atrophy or dystrophy or cardiac pathology up to 1 year of age
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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