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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
targeted mutation 1, Richard T Mathias
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
Gja8tm1Rtm/Gja8tm1Rtm involves: 129/Sv * C57BL/6 MGI:3620835

involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8tm1Rtm mutation (0 available); any Gja8 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• the lenses of knockouts are abnormally small compared to wild-type
• lenses deteriorate rapidly after dissection
• the input conductance per unit area of lens surface is higher in nulls
• the central mature fibers have a complete breakdown in homeostasis and develop a dense cataract
• loss of lens pH sensitivity as gap junction gating in response to pH changes in differentiating fibers of the lens is regulated by connexin alpha 8; lenses from knockouts have a limited ability to gate closed in response to acidification
• the intracellular voltage in lenses from knockouts is uniformly depolarized relative to wild-type where there is a voltage gradient with the central-most cells having a positive resting voltage compared to the outermost cells
• knockout lenses rapidly depolarize in the transition from differentiating fibers to mature fibers; there is a dramatic decrease in gap junctional conductance in knockouts
• the coupling conductance of differentiating fibers in lenses of null mice is decreased by 60%; in heterozygotes, it is decreased by 30%

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory