Phenotypes associated with this allele

• Allele Symbol: Cacna1e^tm1.1Beck
• Allele Name: targeted mutation 1.1, Heinz Beck
• Allele ID: MGI:3619022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1e^tm1.1Beck/Cacna1e^tm1.1Beck	involves: 129P2/OlaHsd * C57BL/6	MGI:3620071

Genotype
MGI:3620071

hm1

• Allelic Composition: Cacna1e^tm1.1Beck/Cacna1e^tm1.1Beck
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased channel response intensity ( J:105917 )

• otherwise completely normal animals with decreased R-type currents in various regions of the brain

• CA1 currents reduced by 79%

• neocortical currents reduced 87%

• dentate granule cell currents decreased about 50%

increased channel response threshold ( J:105917 )

• more hyperpolarized threshold of activation in CA1 and dentate granule neurons