Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation
(2 available);
any
Foxg1 mutation
(28 available)
Olig2tm1Qrlu mutation
(0 available);
any
Olig2 mutation
(46 available)
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nervous system
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• no myelination in dorsal cortex while myelination in ventral cortex is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1tm1(cre)Ito mutation
(1 available);
any
Emx1 mutation
(34 available)
Olig2tm1Qrlu mutation
(0 available);
any
Olig2 mutation
(46 available)
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nervous system
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• severe dysmyelination in cortex while ventral forebrain is normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2tm1Qrlu mutation
(0 available);
any
Olig2 mutation
(46 available)
Tg(GFAP-cre)25Mes mutation
(2 available)
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behavior/neurological
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• abnormal limb clasping reflex
• beginning at 2 weeks of age
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• beginning at 2 weeks of age
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nervous system
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• severe reduction in numbers of myelinated axons and myelin sheaths are thinner
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• development arrested in dorsal cortex before formation of cells capable of forming myelin
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