Phenotypes associated with this allele

• Allele Symbol: Chrm5^tm1Minm
• Allele Name: targeted mutation 1, Minoru Matsui
• Allele ID: MGI:3613514
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrm5^tm1Minm/Chrm5^tm1Minm	B6.129X1-Chrm5^tm1Minm	MGI:3616716
cx2	Chrm1^tm1Kano/Chrm1^tm1Kano Chrm5^tm1Minm/Chrm5^tm1Minm	involves: 129X1/SvJ * C57BL/6	MGI:3616717

Genotype
MGI:3616716

hm1

• Allelic Composition: Chrm5^tm1Minm/Chrm5^tm1Minm
• Genetic Background: B6.129X1-Chrm5^tm1Minm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased digestive secretion ( J:104782 )

• decrease in gastric acid secretion in response to carbachol, with a significant decrease in cumulative acid output compared to wild type

• gastric mucosal histology is normal

homeostasis/metabolism

abnormal histamine physiology ( J:104782 )

• carbachol-stimulated histamine secretion is significantly decreased compared with stimulated secretion in wild type

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:105126 )

N • carbachol-induced intracellular calcium concentration increases in submandibular gland cells are indistinguishable from wild-type, indicating normal salivation

Genotype
MGI:3616717

cx2

• Allelic Composition: Chrm1^tm1Kano/Chrm1^tm1Kano; Chrm5^tm1Minm/Chrm5^tm1Minm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

digestive/alimentary system

decreased digestive secretion ( J:104782 )

• decrease in gastric acid secretion in response to carbachol, with a significant decrease in cumulative acid output compared to wild type

• however gastric mucosal histology is normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:105126 )

N • no difference in pilocarpine-induced salivation from wild-type or in the frequency of prandial drinking, indicating normal salivation