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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scn8a7J
7 Jackson
MGI:3612949
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scn8a7J/Scn8a7J involves: BALB/cByJ * C57BL/6J MGI:3612972


Genotype
MGI:3612972
hm1
Allelic
Composition
Scn8a7J/Scn8a7J
Genetic
Background
involves: BALB/cByJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn8a7J mutation (1 available); any Scn8a mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• upon being lifted by their tails, mutants keep their hind legs close, and their torsos flex backward
• from about 3.7 weeks of age, homozygous mutant mice exhibit a tottering gait with swaying of the torso
• hind legs of mutant mice from about 3.7 weeks of age are held close to their bodies and appear to have limited movement capacity
• from about 3.7 weeks of age, homozygous mutants exhibit intense head tossing
• mutants' forelegs exhibit intermittent clonic spasms

muscle
• mutants' forelegs exhibit intermittent clonic spasms
• standard pathology examination of the hind limb muscles of three mice aged 77, 78 and 110 days revealed regions occupied by very small muscle fibers
• standard pathology examination revealed neurogenic myopathy of the hind limbs, with replacement of muscle by fat, in three older mice (ages 77, 78 and 110 days) examined; no abnormalities were seen in muscles of two 20 day old mice

nervous system
• mutants' forelegs exhibit intermittent clonic spasms
• standard pathology examination revealed loss of granule cells in the cerebella of the three older mice (ages 77, 78 and 110 days) examined; no abnormalities were seen in two 20 day old mice
• standard pathology examination revealed vacuolation of the ventral spinal cord roots in a single mouse, of 4 examined, older than 76 days
• standard pathology examination revealed degenerating nerve fibers in hind limb muscles of three mice aged 77, 78 and 110 days





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory