Phenotypes associated with this allele

• Allele Symbol: Nr1i2^tm1Sakl
• Allele Name: targeted mutation 1, Steven A Kliewer
• Allele ID: MGI:3609633
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1i2^tm1Sakl/Nr1i2^tm1Sakl	involves: 129S1/Sv * 129X1/SvJ	MGI:4437968
hm2	Nr1i2^tm1Sakl/Nr1i2^tm1Sakl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3611180

Genotype
MGI:4437968

hm1

• Allelic Composition: Nr1i2^tm1Sakl/Nr1i2^tm1Sakl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:157882 )

• in non-pregnant mice

cellular

decreased hepatocyte proliferation ( J:157882 )

• in non-pregnant mice

Genotype
MGI:3611180

hm2

• Allelic Composition: Nr1i2^tm1Sakl/Nr1i2^tm1Sakl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal enzyme/coenzyme level ( J:103505 )

• liver basal levels of Cyp3a11 are increased about 4-fold and Cyp7a1 levels are decreased about 2-fold

abnormal physiological response to xenobiotic ( J:103505 )

• treatment with pregnenolone-16alpha-carbonitrile (PCN) fails to induce Cyp3a11 and Slco1a4 or repress Cyp7a1 expression, unlike in wild-type mice

• treatment with PCN fails to protect homozygotes from lithocholic acid-induced hepatotoxicity

decreased physiological sensitivity to xenobiotic ( J:103235 )

• homozygotes do not develop PCN-induced hepatomegaly

behavior/neurological

impaired behavioral response to xenobiotic ( J:103505 )

• homozygotes are paralyzed for a shorter time (6 min) after zoxazolamine treatment compared to wild-type mice (26 min); however, PCN-treatment has no effect on the length of time mutants are paralyzed unlike in wild-type mice where PCN treatment decreases paralysis time to 2 min