About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tlr1tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3609369
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tlr1tm1Aki/Tlr1tm1Aki involves: 129P2/OlaHsd * C57BL/6 MGI:3700170


Genotype
MGI:3700170
hm1
Allelic
Composition
Tlr1tm1Aki/Tlr1tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr1tm1Aki mutation (1 available); any Tlr1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages show impaired proinflammatory cytokine production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein
• macrophages show impaired IL-6 production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein
• macrophages show impaired TNF-alpha production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/31/2020
MGI 6.15
The Jackson Laboratory