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Allele Symbol Allele Name Allele ID |
Shox2tm1Ypc targeted mutation 1, YiPing Chen MGI:3605739 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the sinoatrial node (SAN) is hypoplastic at E11.5
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• the sinoatrial node (SAN) is hypoplastic at E11.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 63% of embryos die between E11.5 and E12.5
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• PCNA staining showed a decreased level of mesenchymal cell proliferation in the anterior regions of the palate at E12.5
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• at E12.5 the anterior palate appears slightly shorter and decreased cell proliferation is seen in the anterior epithelium and mesenchyme
• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
• an increased level of apoptosis was detected in the anterior palatal epithelium at E13.5
• a decreased level of cell proliferation, assayed by PCNA staining, was detected in the anterior regions, in both epithelium and mesenchyme, of the palate at E12.5
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• at E13.5, the palatal shelves are dramatically growth retarded, appear broader due to a shallow ventrolateral indentation, and display increased apoptosis in the anterior epithelium; however, the posterior palate formation is normal
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• at E14.5 the palatal shelves have elevated over the tongue but only make contact at the midline in the posterior region
• at E15.0, a cleft remained in the anterior palate where the hard palate (anterior two-thirds of the palate) forms, while the posterior region of the palate began to fuse, as indicated by the disruption of the midline seam
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• incomplete clefting of the anterior palate which at E15 extends from the anterior extremity of the secondary palate to the first molar level
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• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
|
|
• PCNA staining showed a decreased level of mesenchymal cell proliferation in the anterior regions of the palate at E12.5
|
|
• at E12.5 the anterior palate appears slightly shorter and decreased cell proliferation is seen in the anterior epithelium and mesenchyme
• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
• an increased level of apoptosis was detected in the anterior palatal epithelium at E13.5
• a decreased level of cell proliferation, assayed by PCNA staining, was detected in the anterior regions, in both epithelium and mesenchyme, of the palate at E12.5
|
|
• at E13.5, the palatal shelves are dramatically growth retarded, appear broader due to a shallow ventrolateral indentation, and display increased apoptosis in the anterior epithelium; however, the posterior palate formation is normal
|
|
• at E14.5 the palatal shelves have elevated over the tongue but only make contact at the midline in the posterior region
• at E15.0, a cleft remained in the anterior palate where the hard palate (anterior two-thirds of the palate) forms, while the posterior region of the palate began to fuse, as indicated by the disruption of the midline seam
|
|
• incomplete clefting of the anterior palate which at E15 extends from the anterior extremity of the secondary palate to the first molar level
|
|
• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
|
|
• PCNA staining showed a decreased level of mesenchymal cell proliferation in the anterior regions of the palate at E12.5
|
|
• at E12.5 the anterior palate appears slightly shorter and decreased cell proliferation is seen in the anterior epithelium and mesenchyme
• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
• an increased level of apoptosis was detected in the anterior palatal epithelium at E13.5
• a decreased level of cell proliferation, assayed by PCNA staining, was detected in the anterior regions, in both epithelium and mesenchyme, of the palate at E12.5
|
|
• at E13.5, the palatal shelves are dramatically growth retarded, appear broader due to a shallow ventrolateral indentation, and display increased apoptosis in the anterior epithelium; however, the posterior palate formation is normal
|
|
• at E14.5 the palatal shelves have elevated over the tongue but only make contact at the midline in the posterior region
• at E15.0, a cleft remained in the anterior palate where the hard palate (anterior two-thirds of the palate) forms, while the posterior region of the palate began to fuse, as indicated by the disruption of the midline seam
|
|
• incomplete clefting of the anterior palate which at E15 extends from the anterior extremity of the secondary palate to the first molar level
|
|
• at E17.5, the secondary palate failed to fuse with the primary palate and the nasal septum
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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