Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Dgen mutation
(1 available);
any
Scn11a mutation
(86 available)
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behavior/neurological
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• after treatment with formalin, homozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection), thermal hyperalgesia is less prolonged after treatment with carrageenan or complete Freund's adjuvant and absent after treatment with PGE2
• homozygous mice display length, weight, blood chemistry, fertility, lifespan, and thermal and mechanical nociception similar to wild-type
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Allelic
Composition |
Scn11atm1Dgen/Scn11a+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn11atm1Dgen mutation
(1 available);
any
Scn11a mutation
(86 available)
|
|
|
behavior/neurological
|
|
• after treatment with formalin, heterozygous mice display decreased pain-related behavior during the late phase (10-45 minutes after injection) and thermal hyperalgesia is less prolonged after treatment with complete Freund's adjuvant
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Analysis Tools