Phenotypes associated with this allele

• Allele Symbol: Gngt1^tm1Yf
• Allele Name: targeted mutation 1, Yoshitaka Fukada
• Allele ID: MGI:3603438
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gngt1^tm1Yf/Gngt1^tm1Yf	involves: 129P2/OlaHsd * C57BL/6J	MGI:3608625

Genotype
MGI:3608625

hm1

• Allelic Composition: Gngt1^tm1Yf/Gngt1^tm1Yf
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:101020 )

N • retinal morphology appears normal even at 6 months of age

N • rod responses are not affected under dark-adapted conditions

photosensitivity ( J:101020 )

• light adaptation is impaired in response to 100 lux and to a lesser degree in response to 250 lux

• more geranylgeranylated GNGT1 remained membrane associated in the retina in response to light than did wild-type farnesylated GNGT1

homeostasis/metabolism

photosensitivity ( J:101020 )

• light adaptation is impaired in response to 100 lux and to a lesser degree in response to 250 lux

• more geranylgeranylated GNGT1 remained membrane associated in the retina in response to light than did wild-type farnesylated GNGT1