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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spred2Gt(XB228)Byg
gene trap XB228, BayGenomics
MGI:3590299
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:3603325


Genotype
MGI:3603325
hm1
Allelic
Composition
Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred2Gt(XB228)Byg mutation (0 available); any Spred2 mutation (209 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Achondroplasia-like dwarfism in Spred2Gt(XB228)Byg/Spred2Gt(XB228)Byg mice

growth/size/body
• smaller at birth and stay small throughout life, however levels of testosterone, estrogen, thyroid stimulating hormone, and thyroxin are normal
• more pronounced in males than females, although seen in both

reproductive system
• average litter size is 4.4 pups compared to 8.4 pups in wild-type

hematopoietic system
• increase in number of megakaryocytes in the spleen

skeleton

limbs/digits/tail

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondroplasia; ACH 100800 J:100826





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory