Phenotypes associated with this allele

• Allele Symbol: Il3^tm1Tyb
• Allele Name: targeted mutation 1, Victor L J Tybulewicz
• Allele ID: MGI:3586300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Csf2rb^tm1Mur/Csf2rb^tm1Mur Il3^tm1Tyb/Il3^tm1Tyb	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3604115

Genotype
MGI:3604115

cx1

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur; Il3^tm1Tyb/Il3^tm1Tyb
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of peritoneal and gastrointestinal mast cells, other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

• severity and progress of inflammation are similar to that in Csf2rb1 single homozygotes

respiratory system

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

• severity and progress of inflammation are similar to that in Csf2rb1 single homozygotes

abnormal pulmonary alveolus morphology ( J:35829 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:35829 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of peritoneal and gastrointestinal mast cells, other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal