Phenotypes associated with this allele

• Allele Symbol: Npr2^cn-3J
• Allele Name: achondroplasia 3 Jackson
• Allele ID: MGI:3583746
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Npr2^cn-3J/Npr2^cn-3J	MRL/MpJ-Npr2^cn-3J/GrsrJ	MGI:4947978

Genotype
MGI:4947978

hm1

• Allelic Composition: Npr2^cn-3J/Npr2^cn-3J
• Genetic Background: MRL/MpJ-Npr2^cn-3J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Disproportionate dwarf phenotype in Npr2^cn-3J/Npr2^cn-3J mice

growth/size/body

short snout ( J:170669 )

disproportionate dwarf ( J:170669 )

• homozygotes have a shorter body length, short noses, short limbs, short tails, and squared bellies

limbs/digits/tail

micromelia ( J:170669 )

short tail ( J:170669 )

craniofacial

short snout ( J:170669 )

reproductive system

reduced fertility ( J:170669 )

• male homozygotes are not able to breed, but this is not due to a sperm defect since sperm functions satisfactorily for in vitro fertilization

decreased litter size ( J:170669 )

• female homozygotes breed poorly and have small litter sizes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
achondroplasia		DOID:4480	OMIM:100800	J:170669