Phenotypes associated with this allele

• Allele Symbol: Hus1^tm1.1Rsw
• Allele Name: targeted mutation 1.1, Robert S Weiss
• Allele ID: MGI:3583576
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hus1^tm1.1Rsw/Hus1^tm1.1Rsw	involves: 129S4/SvJaeSor * 129S6/SvEvTac	MGI:3590175

Genotype
MGI:3590175

hm1

• Allelic Composition: Hus1^tm1.1Rsw/Hus1^tm1.1Rsw
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99339 )

• embryos are present at E10.5 but absent at E11.5

embryo

abnormal vitelline vasculature morphology ( J:99339 )

• the yolk sac is poorly vascularized

increased embryonic tissue cell apoptosis ( J:99339 )

• increased numbers of apoptotic cells are seen in embryonic and extraembryonic tissues at E7.0 - E8.5; however, cell proliferation appears normal

abnormal developmental patterning ( J:99339 )

• the uniformity and symmetry seen in wild-type embryos is absent

abnormal embryo turning ( J:99339 )

• embryos fail to undergo axial turning

embryonic growth arrest ( J:99339 )

• embryos arrest by E10.5

embryonic growth retardation ( J:99339 )

• delayed development is seen in some embryos at E8.0

decreased embryo size ( J:99339 )

• embryos are slightly smaller than wild-type littermates at E7.5 and severely reduced in size by E8.5

abnormal neural tube morphology ( J:99339 )

• at E8.5 cell debris is seen in the neural tube

incomplete rostral neuropore closure ( J:99339 )

• at E9.5 only rare embryos display closure of the head folds

kinked neural tube ( J:99339 )

• in the posterior of the embryo, kinking of the neural tube is common

abnormal somite development ( J:99339 )

• at E9.5 embryos have fewer somites than control littermates

failure of chorioallantoic fusion ( J:99339 )

• occasional failure of chorioallantoic fusion is seen

cellular

increased embryonic tissue cell apoptosis ( J:99339 )

• increased numbers of apoptotic cells are seen in embryonic and extraembryonic tissues at E7.0 - E8.5; however, cell proliferation appears normal

nervous system

abnormal neural tube morphology ( J:99339 )

• at E8.5 cell debris is seen in the neural tube

incomplete rostral neuropore closure ( J:99339 )

• at E9.5 only rare embryos display closure of the head folds

kinked neural tube ( J:99339 )

• in the posterior of the embryo, kinking of the neural tube is common

growth/size/body

embryonic growth retardation ( J:99339 )

• delayed development is seen in some embryos at E8.0

decreased embryo size ( J:99339 )

• embryos are slightly smaller than wild-type littermates at E7.5 and severely reduced in size by E8.5

cardiovascular system

abnormal vitelline vasculature morphology ( J:99339 )

• the yolk sac is poorly vascularized