Analysis Tools
immune system
|
• show a modest (about 66%) but significant reduction in T cell numbers in the spleen
• numbers of both T and B cells in lymph nodes are about 1.5-fold higher than in wild-type
|
|
• observe a 50% reduction in the B220hiIgMlo population in the bone marrow but show normal relative and absolute numbers of B220+ and B200+IgM+ B cells
|
|
• relative numbers of IgMhiIgDloCD21hiCD23lo marginal zone B (MZB) cells in the spleen is 1/3 to 1/6 of that seen in wild-type
|
|
• under uninduced conditions, observe decreased basal migration, or chemokinesis, of T and B cells in a transwell assay
• marginal zone B cells show substantially enhanced migration in response to serum, both increase in chemokinesis and chemotaxis
• in response to the TXA2 analog U46619 and LPA, both T and B cells show a profound reduction in actin polymerization, however show no differences in platelet shape change or aggregration
|
|
• basal proliferation of splenic B cells is normal, however B cell responses to anti-IgM stimulation and lipopolysaccharide are reduced
• B cell proliferation to anti-CD40 and IL-4 is slightly reduced
|
|
• basal proliferation of T cells after 2 days of culture in the absence of stimulator cells is increased compared to wild-type cells and after culture, T cells maintain a rate of uninduced proliferation that is higher than wild-type cells
• in the presence of allogenic T cell-depleted splenocytes, T cells do show increased proliferation, indicating that they are able to respond to stimulating cells
• lymph node T cells stimulated with anti-CD3 or ConA show increased basal proliferation compared with wild-type
|
|
• exhibit significantly reduced concentrations of IgG1 and IgG3 upon immunization with a thymus dependent or thymus independent antigen and reduced concentrations of IgG2a and IgG2b upon immunization with a thymus dependent antigen
|
|
• exhibit significantly reduced concentrations of IgM upon immunization with a thymus dependent or thymus independent antigen
|
|
• exhibit impaired humoral immunity
|
hematopoietic system
|
• show a modest (about 66%) but significant reduction in T cell numbers in the spleen
• numbers of both T and B cells in lymph nodes are about 1.5-fold higher than in wild-type
|
|
• observe a 50% reduction in the B220hiIgMlo population in the bone marrow but show normal relative and absolute numbers of B220+ and B200+IgM+ B cells
|
|
• relative numbers of IgMhiIgDloCD21hiCD23lo marginal zone B (MZB) cells in the spleen is 1/3 to 1/6 of that seen in wild-type
|
|
• under uninduced conditions, observe decreased basal migration, or chemokinesis, of T and B cells in a transwell assay
• marginal zone B cells show substantially enhanced migration in response to serum, both increase in chemokinesis and chemotaxis
• in response to the TXA2 analog U46619 and LPA, both T and B cells show a profound reduction in actin polymerization, however show no differences in platelet shape change or aggregration
|
|
• basal proliferation of splenic B cells is normal, however B cell responses to anti-IgM stimulation and lipopolysaccharide are reduced
• B cell proliferation to anti-CD40 and IL-4 is slightly reduced
|
|
• basal proliferation of T cells after 2 days of culture in the absence of stimulator cells is increased compared to wild-type cells and after culture, T cells maintain a rate of uninduced proliferation that is higher than wild-type cells
• in the presence of allogenic T cell-depleted splenocytes, T cells do show increased proliferation, indicating that they are able to respond to stimulating cells
• lymph node T cells stimulated with anti-CD3 or ConA show increased basal proliferation compared with wild-type
|
|
• exhibit significantly reduced concentrations of IgG1 and IgG3 upon immunization with a thymus dependent or thymus independent antigen and reduced concentrations of IgG2a and IgG2b upon immunization with a thymus dependent antigen
|
|
• exhibit significantly reduced concentrations of IgM upon immunization with a thymus dependent or thymus independent antigen
|
cellular
|
• basal proliferation of splenic B cells is normal, however B cell responses to anti-IgM stimulation and lipopolysaccharide are reduced
• B cell proliferation to anti-CD40 and IL-4 is slightly reduced
|
|
• basal proliferation of T cells after 2 days of culture in the absence of stimulator cells is increased compared to wild-type cells and after culture, T cells maintain a rate of uninduced proliferation that is higher than wild-type cells
• in the presence of allogenic T cell-depleted splenocytes, T cells do show increased proliferation, indicating that they are able to respond to stimulating cells
• lymph node T cells stimulated with anti-CD3 or ConA show increased basal proliferation compared with wild-type
|
