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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(GFAP)10Mes
transgene insertion 10, Albee Messing
MGI:3581819
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N MGI:3850532
cx2
Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Tg(GFAP)10Mes/0
involves: 129S4/SvJae * FVB/N MGI:3850511
cx3
Del(9Hspb2-Cryab)1Wawr/+
Tg(GFAP)10Mes/0
involves: 129S4/SvJae * FVB/N MGI:3850514
cx4
Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
involves: 129S4/SvJae * FVB/N MGI:3850529
cx5
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692746
cx6
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
involves: 129S7/SvEvBrd * FVB/N MGI:3850536
cx7
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
involves: FVB/N MGI:3850535
tg8
Tg(GFAP)10Mes/0 involves: FVB/N MGI:3581822


Genotype
MGI:3850532
cx1
Allelic
Composition
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (26 available)
Tg(GFAP)10Mes mutation (0 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age

nervous system
• Rosenthal fibers are observed, but numbers are significantly less than in Gfaptm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced




Genotype
MGI:3850511
cx2
Allelic
Composition
Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Tg(GFAP)10Mes/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• one third of mice null for Cryab show survival to 100 days compared to Cryab-sufficient Tg(GFAP)10Mes mice which display <10% mortality at about 30 days of age; most animals die at about 30 days of age

growth/size/body
• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type

nervous system
• by 3 months of age, animals show formation of ubiquinated astrocytic protein (Rosenthal fiber) aggregates in the hippocampus (dentate gyrus and near pial surface of superior colliculus)




Genotype
MGI:3850514
cx3
Allelic
Composition
Del(9Hspb2-Cryab)1Wawr/+
Tg(GFAP)10Mes/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• two thirds of mice null for Cryab show survival to 100 days compared to Cryab-sufficient Tg(GFAP)10Mes mice which display <10% mortality at about 30 days of age; around 30% of animals die at about 30 days of age




Genotype
MGI:3850529
cx4
Allelic
Composition
Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(9Hspb2-Cryab)1Wawr mutation (0 available); any Del(9Hspb2-Cryab)1Wawr mutation (0 available)
Tg(GFAP)10Mes mutation (0 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• majority of animals (about 90%) survive to 3 months of age

growth/size/body
N
• mice show significantly increased body weights at 6 weeks and three months relative to Tg(GFAP)10Mes and Tg(GFAP)10/Tg(GFAP-Cryab)141.6Mes Cryab-null animals; weights are comparable to wild-type

nervous system
• Rosenthal fibers which outline astrocytic processes are present in mutants




Genotype
MGI:3692746
cx5
Allelic
Composition
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (26 available)
Tg(GFAP)10Mes mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• almost all die at around 30 days of age

nervous system
• two mutants exhibit seizure-like episodes before death
• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant
• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression

behavior/neurological
• two mutants exhibit seizure-like episodes before death

Mouse Models of Human Disease
OMIM ID Ref(s)
Alexander Disease; ALXDRD 203450 J:114689




Genotype
MGI:3850536
cx6
Allelic
Composition
Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background
involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (26 available)
Tg(GFAP)10Mes mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all animals die by under 50 days of age (most die around 30 days)

nervous system
• Rosenthal fiber formation is observed

Mouse Models of Human Disease
OMIM ID Ref(s)
Alexander Disease; ALXDRD 203450 J:146191




Genotype
MGI:3850535
cx7
Allelic
Composition
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(GFAP)10Mes mutation (0 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfaptm2Hgmn/+/+ mice




Genotype
MGI:3581822
tg8
Allelic
Composition
Tg(GFAP)10Mes/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• severely affected mice die around 14 days of age; less affected mice live for more than 1 year
• mice display <10% mortality at about 30 days of age

growth/size/body
• mice show significantly decreased body weights at 6 weeks and three months relative to wild-type

nervous system
• astrocytes are enlarged and contain large eosinophilic aggregations resembling Rosenthal fibers;

Mouse Models of Human Disease
OMIM ID Ref(s)
Alexander Disease; ALXDRD 203450 J:99256





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory