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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akt3tm1Hem
targeted mutation 1, Brian A Hemmings
MGI:3580101
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akt3tm1Hem/Akt3tm1Hem involves: 129P2/OlaHsd * C57BL/6 MGI:3580267
cn2
 		Akt1tm1Zzy/Akt1tm1Zzy
Akt3tm1Hem/Akt3tm1Hem
Tg(Myh6-cre)1Xya/0 		involves: 129P2/OlaHsd * FVB MGI:5563578
cx3
 		Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem 		involves: 129P2/OlaHsd * C57BL/6 MGI:3691594
cx4
 		Akt1tm1Hem/Akt1tm1Hem
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem 		involves: 129P2/OlaHsd * C57BL/6 MGI:3691595
cx5
 		Akt1tm1Hem/Akt1+
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem 		involves: 129P2/OlaHsd * C57BL/6 MGI:3691596


Genotype
MGI:3580267
hm1
Allelic
Composition		 Akt3tm1Hem/Akt3tm1Hem
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3tm1Hem mutation (0 available); any Akt3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to neuronal excitotoxicity ( J:98804 )
• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype
decreased brain size ( J:98804 )
• first observed at 1 month of age and continued in adulthood, however homozygotes are viable, show no growth retardation and have normal glucose metabolism
• whole brain volume was reduced by about 24%
• reduced cell size and cell number in the adult brain
decreased brain weight ( J:98804 )
• about 25% reduction in adult brain weight, however at birth, brain weight did not differ from wildtype
abnormal brain ventricle morphology ( J:98804 )
• reduced volume of the ventricular spaces
decreased corpus callosum size ( J:98804 )
• reduced thickness of the corpus callosum

homeostasis/metabolism
increased susceptibility to neuronal excitotoxicity ( J:98804 )
• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype

cellular
increased susceptibility to neuronal excitotoxicity ( J:98804 )
• hippocampal neuron cultures were more susceptible to glutamate and staurosporine induced cell death than in wildtype




Genotype
MGI:5563578
cn2
Allelic
Composition		 Akt1tm1Zzy/Akt1tm1Zzy
Akt3tm1Hem/Akt3tm1Hem
Tg(Myh6-cre)1Xya/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Zzy mutation (0 available); any Akt1 mutation (34 available)
Akt3tm1Hem mutation (0 available); any Akt3 mutation (42 available)
Tg(Myh6-cre)1Xya mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal physiological response to xenobiotic ( J:206783 )
• following myocardial infarction, rapamycin-treated mice exhibit reduced heart weight compared with untreated mice
• however, rapamycin treatment following myocardial infarction fail to exhibit a change in fibrotic index, ejection fraction, fractional shortening or left ventricular internal diameter at end-diastole

cardiovascular system
decreased heart weight ( J:206783 )
• following myocardial infarction, rapamycin-treated mice exhibit reduced heart weight compared with untreated mice




Genotype
MGI:3691594
cx3
Allelic
Composition		 Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3tm1Hem mutation (0 available); any Akt3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:114675 )
• viable and fertile and showed no obvious abnormalities, except for their smaller size
decreased body weight ( J:114675 )
• in male an average decrease in body weight of 25% persisted throughout life
• in female an average decrease in body weight of 14% from the forth week of age onward

nervous system
decreased brain weight ( J:114675 )
• approximately 35% reduction in brain weight of 3-month old mice

endocrine/exocrine glands
abnormal testis morphology ( J:114675 )
• showed an approximately 1.5 fold increase in apoptotic cells in testis
decreased testis weight ( J:114675 )
• approximately 40% reduction in testis weight of 3-month old mice

reproductive system
abnormal testis morphology ( J:114675 )
• showed an approximately 1.5 fold increase in apoptotic cells in testis
decreased testis weight ( J:114675 )
• approximately 40% reduction in testis weight of 3-month old mice

homeostasis/metabolism
hyperglycemia ( J:114675 )
• observed under random feeding condition
decreased circulating testosterone level ( J:114675 )
• approximately 70% reduction
increased circulating insulin level ( J:114675 )
• plasma insulin levels were significantly higher under both random feeding and fasting conditions
impaired glucose tolerance ( J:114675 )
• susceptibility to glucose intolerance in male
insulin resistance ( J:114675 )
• reduced insulin sensitivity in both male and female mice




Genotype
MGI:3691595
cx4
Allelic
Composition		 Akt1tm1Hem/Akt1tm1Hem
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Hem mutation (0 available); any Akt1 mutation (34 available)
Akt2tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3tm1Hem mutation (0 available); any Akt3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:114675 )
• no triple homozygous mice were obtained from appropriate crosses implying embryonic lethality




Genotype
MGI:3691596
cx5
Allelic
Composition		 Akt1tm1Hem/Akt1+
Akt2tm1Hem/Akt2tm1Hem
Akt3tm1Hem/Akt3tm1Hem
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1tm1Hem mutation (0 available); any Akt1 mutation (34 available)
Akt2tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3tm1Hem mutation (0 available); any Akt3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:114675 )
• viable and fertile and showed no obvious defects except for a severe growth deficiency
decreased body weight ( J:114675 )
• body weight at the age of 12 weeks reduced around 40% of wild-type




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory