Mouse Genome Informatics
cn1
    Nkx3-2tm1(cre)Tsa/Nkx3-2+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa

involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
digestive/alimentary system
• altered radial patterning and anterior-posterior axis patterning of the stomach
• mesenchyme of the stomach was thickened at E16.5
• hind-stomach was expanded and exhibited a vacuolated epithelium, resembling the pyloric region, with numerous invaginations and a thickened and disorganized circular smooth muscle layer
• the pylorus exhibited a disorganized thickened circular smooth muscle layer, with an epithelium that resembled the epithelium of the duodenum and was devoid of vacuoles, unlike the highly vacuolated control
• number of parietal cells increased in the thickened epithelial layer at E18.5
• thicker epithelium at E12.5, E13.5 and E18.5
• the fore-stomach epithelium did not show signs of stratification at E16.5 and resembled hind-stomach epithelium, indicating posteriorization of stomach
• exhibited more extensive invagination of the epithelium than in controls
• thicker glandular epithelium at E16.5, however differentiation of this epithelium was unchanged
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed
• slightly smaller stomach at E12.5 than controls
• reduced size of fore-stomach as indicated by an anterior shift of the limited ridge

nervous system
• expansion of enteric neurons in the stomach

muscle
• the circular smooth muscle layer of the stomach was disorganized at E13.5, E14.5 and E15.5 and was thickened in both the fore-stomach and hind-stomach, suggesting that radial patterning of the stomach was perturbed

Mouse Models of Human Disease
OMIM IDRef(s)
Diaphragmatic Hernia, Congenital 142340 J:103437