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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		H1f6tm1Drab
targeted mutation 1, Birgit Drabent
MGI:3578782
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		H1f6tm1Drab/H1f6tm1Drab involves: 129P2/OlaHsd * C57BL/6J MGI:3579034
cx2
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579102
cx3
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579109
cx4
 		H1f6tm1Drab/H1f6+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen 		involves: 129 * C57BL/6J MGI:3579110
cx5
 		H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+ 		involves: 129 * C57BL/6J MGI:3579115
cx6
 		Acrtm1Wen/Acrtm1Wen
H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen 		involves: 129/Sv * C57BL/6J * CD-1 MGI:3579101


Genotype
MGI:3579034
hm1
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:98592 )
• homozygous null mice develop normally and exhibit normal testicular morphology, spermatogenesis and fertility, although Hist1h1a (H1.1), Hist1h1c (H1.2) and Hist1h1e (H1.4) gene expression was enhanced during spermatogenesis




Genotype
MGI:3579102
cx2
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice

reproductive system
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type, however did not observe reduced migration of sperm in the female genital tract
• smaller decrease in sperm motility than seen in triple homozygous Acr/Hist1-1s/Mcsp and Acr/Hist1h1t/Mcsp mice
male infertility ( J:98301 )
• produced no offspring when mated to wild-type females
impaired fertilization ( J:98301 )
• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
impaired sperm penetration of zona pellucida ( J:98301 )
• impaired sperm penetration of zona pellucida from wild-type females




Genotype
MGI:3579109
cx3
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcp+
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:98301 )
N
• male fertility is normal




Genotype
MGI:3579110
cx4
Allelic
Composition		 H1f6tm1Drab/H1f6+
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2tm1Wen
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:98301 )
• fertility of males is reduced to 20%-50% of controls




Genotype
MGI:3579115
cx5
Allelic
Composition		 H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Tnp2tm1Wen/Tnp2+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
Tnp2tm1Wen mutation (0 available); any Tnp2 mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system




Genotype
MGI:3579101
cx6
Allelic
Composition		 Acrtm1Wen/Acrtm1Wen
H1f6tm1Drab/H1f6tm1Drab
Smcptm1Wen/Smcptm1Wen
Genetic
Background		 involves: 129/Sv * C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acrtm1Wen mutation (0 available); any Acr mutation (46 available)
H1f6tm1Drab mutation (0 available); any H1f6 mutation (17 available)
Smcptm1Wen mutation (0 available); any Smcp mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm head morphology ( J:98301 )
• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice
reduced male fertility ( J:98301 )
• litter size was sharply reduced when mutant males were mated to wild-type females
impaired fertilization ( J:98301 )
• only 8%-15% of wild-type oocytes were fertilized by mutant sperm (compared to 84.8% by wild-type sperm), but 71-75% of the fertilized oocytes developed into normal blastocysts (compared to 61.5% of the controls)
impaired binding of sperm to zona pellucida ( J:98301 )
• reduced binding of sperm to zona pellucida from wild-type females

cellular
abnormal sperm head morphology ( J:98301 )
• 18% of sperm (compared to 7.7% of wild-type) had abnormal sperm head shapes that were broader and less pointed than wild-type
impaired sperm migration in female genital tract ( J:98301 )
• reduced number of sperm in oviducts of wild-type females, indicating that migration of sperm through the female genital tract is impaired
asthenozoospermia ( J:98301 )
• significant alterations in sperm velocities, beat frequency, amplitude, straightness threshold and forward movement, indicating decreased sperm motility compared to wild-type
• greater decrease in sperm motility than in triple homozygous Tnp2/Hist1h1t/Mcsp mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory