Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7tm1Ttg mutation
(2 available);
any
Irf7 mutation
(23 available)
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mortality/aging
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• in PR8M virus-infected mice
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immune system
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• a low pathogenic A/Puerto Rico/8/1934 H1N1 (PR8M) virus-infected mice exhibit increased weight loss and mortality compared with wild-type mice
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• in PR8M virus-infected mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf7tm1Ttg mutation
(2 available);
any
Irf7 mutation
(23 available)
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immune system
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• induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonisits, was severely impaired
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• reduced total type-1 interferon (IFN) activity in the supernatant of mutant MEFs infected with herpes simplex virus type 1 (HSV-1), encephalomyocarditis virus (EMCV) or vesicular stomatitis virus (VSV) compared to controls
• decrease in serum type-1 IFN levels after viral infection (with HSV-1 or EMCV)
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• more vulnerable to HSV-1 infection than wild-type or homozygous Irf3 or Myd88 mutant mice
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• more vulnerable to EMCV infection than wild-type or homozygous Irf3 or Myd88 mutant mice
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homeostasis/metabolism
hematopoietic system
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• induction of the antigen-specific CD8+ T-cell response by immunizing with soluble ovalbumin and TLR9 agonists, but not TLR2 and TLR6 agonisits, was severely impaired
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immune system
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• F. tularensis live vaccine strain-, Sendai virus-, or synthetic B-form dsDNA (poly-dA:dT)-treated thioglycollate-elicited macrophages secrete less IFN-beta than similarly treated wild-type cells
• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells
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• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B than similarly treated wild-type cells
• however, synthetic B-form dsDNA (poly-dA:dT)-treated mice produce normal amounts of IL1-beta
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• F. tularensis live vaccine strain-treated thioglycollate-elicited macrophages secrete less IL1B and IFN-beta than similarly treated wild-type cells
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• mCMV-treated thioglycollate-elicited macrophages fail to secrete IFN-beta unlike similarly treated wild-type cells
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• Sendai virus-treated splenocytes secrete less IFN-beta than similarly treated wild-type cells
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