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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhpn2tm1Ssch
targeted mutation 1, Stephanie Schurmans
MGI:3577068
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rhpn2tm1Ssch/Rhpn2tm1Ssch involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3577337
cx2
 		Rhpn1tm1Ktry/Rhpn1tm1Ktry
Rhpn2tm1Ssch/Rhpn2tm1Ssch 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:6360616


Genotype
MGI:3577337
hm1
Allelic
Composition		 Rhpn2tm1Ssch/Rhpn2tm1Ssch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhpn2tm1Ssch mutation (0 available); any Rhpn2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:97638 )
• homozygous mutants are fertile and have normal body weight and size, normal thyroid morphology and function, and normal brain, lung, ovary, testis, and kidney morphology




Genotype
MGI:6360616
cx2
Allelic
Composition		 Rhpn1tm1Ktry/Rhpn1tm1Ktry
Rhpn2tm1Ssch/Rhpn2tm1Ssch
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhpn1tm1Ktry mutation (0 available); any Rhpn1 mutation (34 available)
Rhpn2tm1Ssch mutation (0 available); any Rhpn2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:276466 )
• mice show reduced lifespan

homeostasis/metabolism
albuminuria ( J:276466 )
• albumin/creatinine ratio is increased

renal/urinary system
albuminuria ( J:276466 )
• albumin/creatinine ratio is increased
glomerulosclerosis ( J:276466 )
• segmental and global glomerular sclerosis
renal interstitial fibrosis ( J:276466 )
• interstitial fibrosis in nephrotic kidneys
dilated renal tubule ( J:276466 )
• tubule dilatation in nephrotic kidneys
renal cast ( J:276466 )
• tubular casts in nephrotic kidneys




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory