Phenotypes associated with this allele

• Allele Symbol: Tnf^tm1.2Sned
• Allele Name: targeted mutation 1.2, Sergei A Nedoskasov
• Allele ID: MGI:3576929
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnf^tm1.2Sned/Tnf^tm1.2Sned	involves: 129/Sv * C57BL/6	MGI:3582275

Genotype
MGI:3582275

hm1

• Allelic Composition: Tnf^tm1.2Sned/Tnf^tm1.2Sned
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:97783 )

• a modest increase in peripheral white cell count is seen compared to wild-type mice

absent Peyer's patches ( J:97783 )

• Peyer's patches are absent in adults and Peyer's patch anlagen is absent at E16.5 and in neonates; however homozygotes develop a full set of lymph nodes and do not display signs of lymphotoxin deficiency

decreased susceptibility to bacterial infection ( J:97783 )

• homozygotes are protected from LPS/D-Gal induced shock

increased susceptibility to parasitic infection ( J:97783 )

• homozygotes show increased sensitivity to systemic and alimentary L. monocytogenes infection

hematopoietic system

increased leukocyte cell number ( J:97783 )

• a modest increase in peripheral white cell count is seen compared to wild-type mice