Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation
(0 available);
any
Irf5 mutation
(28 available)
|
|
|
immune system
N |
• mice exhibit normal B cell and plasmacytoid dendritic cell development and IFNalpha production following CpG-A stimulation of dendritic cells
|
|
• 1.3-fold in splenocytes infected with HSV-1
|
|
• 2.0- to 2.4-fold in splenocytes infected with HSV-1
|
|
• from plasmacytoid dendritic cell stimulated with CpG-B or imiquimod
• 5.6- to 7.1-fold in splenocytes infected with HSV-1
|
|
• splenocytes infected with HSV-1 exhibit reduced production of IL6 (2.0- to 2.4-fold), TNF (5.6- to 7.1-fold) and IFNa (1.3-fold) compared with wild-type cells
• mice infected with West Nile virus exhibit a 2.6-fold reduction in anti-WNV IgG2c compared with wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf5tm1Ttg mutation
(0 available);
any
Irf5 mutation
(28 available)
|
|
|
immune system
N |
• mice exhibit normal B cell and plasmacytoid dendritic cell development
|
|
• exhibit a deficiency in the Th1 immune response
|
|
• decrease in serum levels of IL-12p40 in response to LPS or umethylated DNA treatment
|
|
• decrease in serum levels of IL-6 in response to LPS or umethylated DNA treatment
|
|
• decrease in serum levels of TNF-alpha in response to LPS or umethylated DNA treatment
|
|
• resistance to lipopolysaccharide (LPS) and unmethylated DNA (CpG-B) induced endotoxic shock
|
homeostasis/metabolism
hematopoietic system
|
• exhibit a deficiency in the Th1 immune response
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2m1Hsd mutation
(0 available);
any
Dock2 mutation
(142 available)
Irf5tm1Ttg mutation
(0 available);
any
Irf5 mutation
(28 available)
|
|
|
immune system
|
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
|
|
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
|
|
• slight increase in frequency and number in the bone marrow
|
|
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks
|
|
• from plasmacytoid dendritic cell stimulated with CpG-A
|
|
• mice exhibit reduced (7-fold at day 6 and 43-fold at day 9) specific IgG titers compared with wild-type mice
|
hematopoietic system
|
• mice exhibit impaired B cell and plasmacytoid dendritic cell development compared with wild-type mice
• however, expression of Dock2 rescues B cell and plasmacytoid dendritic cell development
|
|
• sharp reduction in the spleen (8.7-fold) and blood (6.2-fold)
• reduced percentage to total leukocytes in the peripheral blood
|
|
• slight increase in frequency and number in the bone marrow
|
|
• frequency (3.1-fold) and number (1.3-fold) at 8 weeks
|