Phenotypes associated with this allele

• Allele Symbol: Osm^tm1Ymo
• Allele Name: targeted mutation 1, Yoshihiro Morikawa
• Allele ID: MGI:3574987
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Osm^tm1Ymo/Osm^tm1Ymo	B6.Cg-Osm^tm1Ymo	MGI:3575503

Genotype
MGI:3575503

hm1

• Allelic Composition: Osm^tm1Ymo/Osm^tm1Ymo
• Genetic Background: B6.Cg-Osm^tm1Ymo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hypoalgesia ( J:97000 )

• displayed reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain

nervous system

abnormal dorsal root ganglion morphology ( J:97000 )

• in the DRGs, vanilloid receptor 1 (VR1)- and P2x3-positive small-sized neurons were decreased

• OSMR-positive neurons are also decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons