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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abca7tm1Frm
targeted mutation 1, Mason W Freeman
MGI:3574592
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abca7tm1Frm/Abca7tm1Frm involves: 129S4/SvJae * C57BL/6 MGI:3574816


Genotype
MGI:3574816
hm1
Allelic
Composition		 Abca7tm1Frm/Abca7tm1Frm
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abca7tm1Frm mutation (0 available); any Abca7 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
decreased white adipose tissue amount ( J:96865 )
• females, but not males, exhibited an approximate 50% reduction in the white adipose tissue mass at 10 weeks of age

homeostasis/metabolism
decreased circulating cholesterol level ( J:96865 )
• total cholesterol was significantly lower in females but not males, however no alterations in serum-free fatty acid levels
decreased circulating HDL cholesterol level ( J:96865 )
• females exhibited a decrease in HDL cholesterol levels

renal/urinary system
small kidney ( J:96865 )
• males exhibit a 10% reduction in kidney size at 10 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory