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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Egr2tm1Jmi
targeted mutation 1, Jeffrey Milbrandt
MGI:3574072
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Egr2tm1Jmi/Egr2tm1Jmi Not Specified MGI:3576120


Genotype
MGI:3576120
hm1
Allelic
Composition
Egr2tm1Jmi/Egr2tm1Jmi
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm1Jmi mutation (0 available); any Egr2 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Runted phenotype and hindbrain defect of Egr2tm1Jmi/Egr2tm1Jmi mice

mortality/aging
• 40% die within the first week of life, the remaining homozygotes survive into the third week of life

behavior/neurological
• severe tremors are seen

growth/size/body

nervous system
• increased numbers of proliferating Schwann cells are seen at P14
• at E10.5, in 14% of mutants both rhombomeres 3 and 5 are absent, in 57% fusion of cranial nerves V, VII, and VIII is seen, and in 29% fusion of cranial nerves IX and X is seen
• an abundance of undifferentiated Schwann cells are seen associated with individual axons of the sciatic nerve (J:96641)
• at postnatal day 14 increased proliferation of Schwann cells is seen with 11.3 +/- 1.9% of the nuclei BrdU+ compared to less than 0.9% in wild-type mice (J:99824)
• at P14 the sciatic nerve is thin and translucent
• the number of large and medium claiber axons is normal but, most lack myelin
• myelination is absent; however, no signs of demyelination are seen (J:96641)

cellular
• increased numbers of proliferating Schwann cells are seen at P14





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory