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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cecr2Gt(pGT1)1Hemc
gene trap 1, Heather E McDermid
MGI:3574034
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc 129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574278
hm2
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc C.129P2-Cecr2Gt(pGT1)1Hemc MGI:3574277
hm3
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574279
hm4
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: 129P2/OlaHsd * BALB/c MGI:3574274
hm5
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: 129P2/OlaHsd * BALB/c * FVB/N MGI:3574276
hm6
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc MGI:3574280
ht7
Cecr2Gt(pGT1)1Hemc/Cecr2+ C.129P2-Cecr2Gt(pGT1)1Hemc MGI:5297953
ht8
Cecr2Gt(pGT1)1Hemc/Cecr2+ involves: 129P2/OlaHsd * BALB/c MGI:3574275


Genotype
MGI:3574278
hm1
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 63% penetrance of exencephaly

Mouse Models of Human Disease
OMIM ID Ref(s)
Anencephaly 206500 J:96325




Genotype
MGI:3574277
hm2
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
C.129P2-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased cranial neural tube width
• 74% penetrance of exencephaly (J:96325)
• penetrance is 74% at N6 and 69% at greater than N10 (J:177709)

embryo
• increased cranial neural tube width

Mouse Models of Human Disease
OMIM ID Ref(s)
Anencephaly 206500 J:96325




Genotype
MGI:3574279
hm3
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• exencephaly penetrance was 0% unlike in other genetic backgrounds
• increased cranial neural tube width
• at the 16 somite stage the neural tube is closed in only about half the embryos
• penetrance is 1.6% at greater than N10

hearing/vestibular/ear
N
• no cochlear defects are detected

embryo
• increased cranial neural tube width
• at the 16 somite stage the neural tube is closed in only about half the embryos

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Anencephaly 206500 J:96325




Genotype
MGI:3574274
hm4
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygous mutants die perinatally, however 7.5% of homozgygotes are found at weaning and these are indistinguishable from wildtype

vision/eye
• some homozygous mutants lacked eyelids

nervous system
• neural tube defect exencephaly was observed at a frequency of 67% in homozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Anencephaly 206500 J:96325




Genotype
MGI:3574276
hm5
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
involves: 129P2/OlaHsd * BALB/c * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 36% penetrance of exencephaly




Genotype
MGI:3574280
hm6
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc
Genetic
Background
involves: C.129P2-Cecr2Gt(pGT1)1Hemc * FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• exencephaly appeared only in one in 35 homozygous mutant embryos




Genotype
MGI:5297953
ht7
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic
Background
C.129P2-Cecr2Gt(pGT1)1Hemc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at the 14 and 16 somite pair stage the percentage of mice with a closed neural tube is decreased compared to wild-type controls

embryo
• at the 14 and 16 somite pair stage the percentage of mice with a closed neural tube is decreased compared to wild-type controls




Genotype
MGI:3574275
ht8
Allelic
Composition
Cecr2Gt(pGT1)1Hemc/Cecr2+
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cecr2Gt(pGT1)1Hemc mutation (0 available); any Cecr2 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• observed exencephaly at a low frequency of 3.5% in heterozygotes





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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory