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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G37R)42Dpr
transgene insertion 42, Donald L Price
MGI:3574014
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SOD1*G37R)42Dpr/0 involves: C3H/HeJ * C57BL/6J MGI:3814058


Genotype
MGI:3814058
tg1
Allelic
Composition
Tg(SOD1*G37R)42Dpr/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SOD1*G37R)42Dpr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in the choroid plexus
• mice exhibit vacuolization in the neutropil of substantia gelatinosa and scattered in some of the fiber tracts of the ventral and lateral white matter of the spinal cord
• at late stages
• motor neuron degeneration is observed in the ventral horns of the lumbar, thoracic, and cervical spinal cord as well as the brain stem
• degeneration is associated with vacuole formation in both dendrites and axons of motor neurons
• mice exhibit axonal degradation in dorsal roots of motor neurons

behavior/neurological
• at 3.5 to 4 months of age, mice exhibit axial tremors
• at 3.5 to 4 months of age, mice exhibit asymmetric weakness of the limbs and when suspended by their tail exhibit difficulties extending and moving hindlimbs
• at 3.5 to 4 months of age, mice exhibit decreased spontaneous movement compared to wild-type mice
• eventually mice develop hindlimb paralysis

muscle
• at 3.5 to 4 months of age, mice exhibit muscle wasting particularly along the flanks
• mice exhibit spontaneous, positive sharp waves associated with denervation atrophy

cellular
• motor neurons exhibit mitochondrial degradation

growth/size/body
• progressive

renal/urinary system
• mice exhibit vacuolization of epithelial cells in the proximal tubules of the kidney

integument
• at 3.5 to 4 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:69178





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory