Phenotypes associated with this allele

• Allele Symbol: Lama1^tm1Ekb
• Allele Name: targeted mutation 1, Peter Ekblom
• Allele ID: MGI:3530455
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lama1^tm1Ekb/Lama1^tm1Ekb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3531419

Genotype
MGI:3531419

hm1

• Allelic Composition: Lama1^tm1Ekb/Lama1^tm1Ekb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:96100 )

• homozygotes die around E6.5

embryo

absent blastocoele ( J:96100 )

• the mutant epiblast is defective in polarization and cavitation

abnormal Reichert's membrane morphology ( J:96100 )

• in 3 out of 14 embryos, the Reichert's membrane (secreted by the parietal endoderm) is present but has poor structural integrity

absent Reichert's membrane ( J:96100 )

• in 8 out of 14 embryos, the Reichert's membrane is partially absent

• in 2 out of 14 embryos, the Reichert's membrane is completely absent