All Phenotypes Rptor<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rptor^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529138

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rptor^tm1Lex/Rptor^tm1Lex	involves: 129S/SvEvBrd	MGI:3802636
hm2	Rptor^tm1Lex/Rptor^tm1Lex	involves: 129S5/SvEvBrd	MGI:3609770
cx3	Pten^tm1Rps/Pten⁺ Rptor^tm1Lex/Rptor⁺	involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6	MGI:4848144

Allelic Composition	Rptor^tm1Lex/Rptor^tm1Lex
Genetic Background	involves: 129S/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptor^tm1Lex mutation (2 available); any Rptor mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:137592 )

• mice implant but fail to expand thereafter and die

embryo

decreased inner cell mass proliferation ( J:137592 )

• inner cell mass explants exhibit reduced expansion in culture unlike wild-type explants

abnormal trophoblast giant cell morphology ( J:137592 )

• explants exhibit reduced expansion in culture unlike wild-type explants

cellular

decreased inner cell mass proliferation ( J:137592 )

• inner cell mass explants exhibit reduced expansion in culture unlike wild-type explants

Allelic Composition	Rptor^tm1Lex/Rptor^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rptor^tm1Lex mutation (2 available); any Rptor mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:103485 )

• no homozygotes seen at weaning; stage of lethality not specified

Allelic Composition	Pten^tm1Rps/Pten⁺ Rptor^tm1Lex/Rptor⁺
Genetic Background	involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Rps mutation (1 available); any Pten mutation (81 available)
Rptor^tm1Lex mutation (2 available); any Rptor mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:144810 )

N	• mutants exhibit a similar lifespan as single heterozygous Pten mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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