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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rgs14tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528963
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rgs14tm1Lex/Rgs14tm1Lex involves: 129S/SvEvBrd * C57BL/6 MGI:4838401
hm2
Rgs14tm1Lex/Rgs14tm1Lex involves: 129S5/SvEvBrd MGI:3609690


Genotype
MGI:4838401
hm1
Allelic
Composition
Rgs14tm1Lex/Rgs14tm1Lex
Genetic
Background
involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs14tm1Lex mutation (2 available); any Rgs14 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal sensory-motor-gating
• CA2 neurons exhibit more action potential spikes following stimulation compared with similarly treated wild-type neurons
• CA2 neurons exhibit increased input resistance compared with wild-type cells
• synaptic plasticity in CA2 neurons is enhanced compared to in wild-type neurons
• in CA2 neurons following high-frequency stimulation (HFS)
• however, long term potentiation (LTP) in CA1 neurons assessed in field potentials is normal and U0126 treatment restores normal LTP following HFS

behavior/neurological
N
• mice exhibit normal swim speed, ambulation, baseline startle response, and anxiety in the elevated plus maze
• after 4 hours, mice spend more time exploring and make more contacts with a novel object indicating enhanced recognition memory compared with wild-type mice
• mice exhibit enhanced initial learning rate in a Morris water maze that is sustained each day compared with wild-type mice
• after 4 hours, mice spend more time exploring and make more contacts with a novel object indicating enhanced recognition memory compared with wild-type mice




Genotype
MGI:3609690
hm2
Allelic
Composition
Rgs14tm1Lex/Rgs14tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgs14tm1Lex mutation (2 available); any Rgs14 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice exhibit normal fertility

homeostasis/metabolism
N
• mice exhibit normal blood chemistry, urine content, and glucose homeostasis

cardiovascular system
N
• mice exhibit normal blood pressure and heart rate

hematopoietic system
N
• mice exhibit normal hematology

immune system
N
• mice exhibit normal immune response to LPS and ovalbumin
• ice exhibit normal T cell morphology

behavior/neurological
N
• mice exhibit normal general behavior, circadian rhythm, nociception, open field behavior, pre-pulse inhibition, tail suspecision behavior, and trace aversive conditioning

vision/eye
N
• mice exhibit normal eye angiogram and fundus morphology

growth/size/body
N
• mice exhibit normal body composition

skeleton
N
• mice exhibit normal bone mineral density and bone architecture

integument
N
• mice exhibit normal skin fibroblast proliferation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory