Phenotypes associated with this allele

• Allele Symbol: Gpr84^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528887
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr84^tm1Lex/Gpr84^tm1Lex	involves: 129S/SvEvBrd * C57BL/6	MGI:5435897

Genotype
MGI:5435897

hm1

• Allelic Composition: Gpr84^tm1Lex/Gpr84^tm1Lex
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:186985 )

N • mice exhibit normal T and B cell proliferation

abnormal T-helper 2 physiology ( J:186985 )

• under TH2 differentiation conditions, CD4+ T cells exhibit reduced secretion of IL4, IL5 and IL13 compared with wild-type cells

• however, mice exhibit normal immune response to ovalbumin

increased interleukin-13 secretion ( J:186985 )

• in CD4+ T cells under TH2 differentiation conditions

increased interleukin-4 secretion ( J:186985 )

• in T cells stimulated with anti-CD3 antibodies with or without anti-CD28 antibodies

• in CD4+ T cells under TH2 differentiation conditions

increased interleukin-5 secretion ( J:186985 )

• in CD4+ T cells under TH2 differentiation conditions

hematopoietic system

abnormal T-helper 2 physiology ( J:186985 )

• under TH2 differentiation conditions, CD4+ T cells exhibit reduced secretion of IL4, IL5 and IL13 compared with wild-type cells

• however, mice exhibit normal immune response to ovalbumin