All Phenotypes Kl<tm1Lex> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kl^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528832

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kl^tm1Lex/Kl^tm1Lex	B6.129S-Kl^tm1Lex	MGI:5052066
hm2	Kl^tm1Lex/Kl^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3609938
cx3	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan	involves: 129S/SvEvBrd * C57BL/6	MGI:5052065

Allelic Composition	Kl^tm1Lex/Kl^tm1Lex
Genetic Background	B6.129S-Kl^tm1Lex

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kl^tm1Lex mutation (1 available); any Kl mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating calcium level ( J:173962 )

increased circulating phosphate level ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 6 weeks

Allelic Composition	Kl^tm1Lex/Kl^tm1Lex
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kl^tm1Lex mutation (1 available); any Kl mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:103485 )

• homozygotes are sickly and most die by 9 to 10 weeks of age

growth/size/body

decreased body weight ( J:103485 )

• body weight, mean total tissue mass, and lean body mass are reduced

decreased body length ( J:103485 )

skeleton

abnormal femur morphology ( J:103485 )

• mean femoral midshaft cortical thickness is reduced

abnormal trabecular bone morphology ( J:103485 )

• mean trabecular bone volume and thickness are increased

limbs/digits/tail

abnormal femur morphology ( J:103485 )

• mean femoral midshaft cortical thickness is reduced

Allelic Composition	Kl^tm1Lex/Kl^tm1Lex Sfrp4^tm1.1Blan/Sfrp4^tm1.1Blan
Genetic Background	involves: 129S/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kl^tm1Lex mutation (1 available); any Kl mutation (53 available)
Sfrp4^tm1.1Blan mutation (0 available); any Sfrp4 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:173962 )

• average life span is 14 to 16 weeks

homeostasis/metabolism

increased circulating phosphate level ( J:173962 )

digestive/alimentary system

abnormal digestive system morphology ( J:173962 )

• mice exhibit intestinal atrophy unlike wild-type mice

respiratory system

emphysema ( J:173962 )

renal/urinary system

nephrocalcinosis ( J:173962 )

cardiovascular system

calcified artery ( J:173962 )

growth/size/body

decreased body size ( J:173962 )

• at 3 and 6 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23