mortality/aging

partial postnatal lethality ( J:95953 )

• reduced postnatal survival similar to Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm (J:95953)

growth/size

decreased birth body size ( J:95953 )

• mutants are smaller at birth (J:95953)

nervous system

loss of hippocampal neurons ( J:95953 )

• not as severe as in Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm (J:95953)

loss of cortex neurons ( J:95953 )

• the frontal cortex is reduced in size especially in the caudal-medial cortex similar to Atrx hemizygotes that are heterozygous for Foxg1^tm1(cre)Skm but the severity of loss is decreased (J:95953)

Mouse Models of Human Disease		OMIM ID	Ref(s)
Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked; ATRX		301040	J:95953