Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2tm1.1Rmgr mutation
(2 available);
any
Tgm2 mutation
(49 available)
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growth/size/body
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N |
• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic 129S1/Sv background exhibit normal weight gain when fed a high fat diet
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2tm1.1Rmgr mutation
(2 available);
any
Tgm2 mutation
(49 available)
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growth/size/body
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• Background Sensitivity: mice on a a congenic C57BL/6 background exhibit increased body weight when fed a high fat diet unlike mice on a congenic 129S1/Sv background
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2tm1.1Rmgr mutation
(2 available);
any
Tgm2 mutation
(49 available)
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cellular
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• fewer homozygous fibroblasts (20% versus 79% of wild-type) adhered to poly-L-coated or fibronectin coated slides
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immune system
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• 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired
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hematopoietic system
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• 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HDexon1)62Gpb mutation
(14 available)
Tgm2tm1.1Rmgr mutation
(2 available);
any
Tgm2 mutation
(49 available)
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mortality/aging
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• mean lifespan of mutants was increased by 19.7% compared Tg(HDexon1)62Gpb transgenic mice
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behavior/neurological
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• mutants showed a delayed onset of motor dysfunction compared to Tg(HDexon1)62Gpb transgenic mice at 9, 10, and 11 weeks of age
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nervous system
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• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice
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• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HDexon1)62Gpb mutation
(14 available)
Tgm2tm1.1Rmgr mutation
(2 available);
any
Tgm2 mutation
(49 available)
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nervous system
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• mutants had more huntingtin protein aggregates within the cerebral cortex and striatum but no difference in the onset of motor dysfunction and the mean lifespan compared to Tg(HDexon1)62Gpb transgenic mice
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• mutants had more huntingtin protein aggregates within the cerebral cortex and striatum but no difference in the onset of motor dysfunction and the mean lifespan compared to Tg(HDexon1)62Gpb transgenic mice
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Analysis Tools