Phenotypes associated with this allele
Allelic Composition |
Sema3etm1Ddg/Sema3etm1Ddg
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Genetic Background |
either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3etm1Ddg mutation
(1 available);
any
Sema3e mutation
(65 available)
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cardiovascular system
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• at E11.5 the intersomitic vessels are disorganized and extend ectopically throughout the somite
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embryo
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• at E11.5 ectopic intersomitic vascular growth results in exuberant growth and loss of the normal segmented pattern
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema3etm1Ddg mutation
(1 available);
any
Sema3e mutation
(65 available)
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The vascular network is disorganized in Sema3etm1Ddg/Sema3etm1Ddg retinas
vision/eye
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• at P4, mice exhibit disordered axonal fibers in the retina compared with wild-type mice
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• at P4, mice exhibit vascular defects in the retina with clusters of retinal ECs, attachment of hyaloid vessels to the retinal surface, disorganized vascular, decreased vascular density remodeling, and ectopic vascular invasion into the ganglion cell layer compared to in wild-type mice
• at P4, vascular pathfinding in the retina is restricted compared to in wild-type mice
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cardiovascular system
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• at P4, mice exhibit vascular defects in the retina with clusters of retinal ECs, attachment of hyaloid vessels to the retinal surface, disorganized vascular, decreased vascular density remodeling, and ectopic vascular invasion into the ganglion cell layer compared to in wild-type mice
• at P4, vascular pathfinding in the retina is restricted compared to in wild-type mice
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