Phenotypes associated with this allele

• Allele Symbol: Icos^tm1Tkan
• Allele Name: targeted mutation 1, T Kanai
• Allele ID: MGI:3526880
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Icos^tm1Tkan/Icos^tm1Tkan	involves: 129S7/SvEvBrd * C57BL/6	MGI:3527951

Genotype
MGI:3527951

hm1

• Allelic Composition: Icos^tm1Tkan/Icos^tm1Tkan
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestine morphology ( J:95728 )

• significantly fewer IgA+ B-cells in the lamina propria

immune system

abnormal NK cell physiology ( J:95353 )

• alpha-galactosylceramide-induced cytotoxic activity of splenic and hepatic mononuclear cells was reduced compared to wild-type

• alpha-galactosylceramide-induced anti-metastatic effect was substantially reduced compared to wild-type, indicating that natural killer cells are not able to fight off cancer cells

decreased circulating interferon-gamma level ( J:95353 )

• alpha-galactosylceramide-induced serum IFN-gamma levels were reduced compared to wild-type

decreased circulating interleukin-4 level ( J:95353 )

• alpha-galactosylceramide-induced (an antigen that activates invariant natural killer T cells) serum IL-4 levels were reduced compared to wild-type

abnormal Peyer's patch germinal center morphology ( J:95728 )

• PNA+ cells were absent in homozygous Peyer's patches, indicating that intestinal germinal centers do not form

small Peyer's patches ( J:95728 )

• size of Peyer's patches was significantly decreased in 4 week old homozygotes, but no differences in the total number of patches

• significantly fewer IgA+ B-cells and IgG+ cells in Peyer's patches

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:95353 )

• alpha-galactosylceramide-induced serum IFN-gamma levels were reduced compared to wild-type

decreased circulating interleukin-4 level ( J:95353 )

• alpha-galactosylceramide-induced (an antigen that activates invariant natural killer T cells) serum IL-4 levels were reduced compared to wild-type

hematopoietic system

abnormal NK cell physiology ( J:95353 )

• alpha-galactosylceramide-induced cytotoxic activity of splenic and hepatic mononuclear cells was reduced compared to wild-type

• alpha-galactosylceramide-induced anti-metastatic effect was substantially reduced compared to wild-type, indicating that natural killer cells are not able to fight off cancer cells