All Phenotypes Kcna2<tm1Tem> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcna2^tm1Tem/Kcna2^tm1Tem	C3Fe.129S7-Kcna2^tm1Tem	MGI:3774494
hm2	Kcna2^tm1Tem/Kcna2^tm1Tem	involves: 129S7/SvEvBrd	MGI:3774506
hm3	Kcna2^tm1Tem/Kcna2^tm1Tem	involves: 129S7/SvEvBrd * C57BL/6	MGI:3774492
ht4	Kcna2^tm1Tem/Kcna2⁺	C3Fe.129S7-Kcna2^tm1Tem	MGI:3774493

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:131735 )

• mice survive 17+/-2 days and likely die due to apnea during tonic extension

• observed seizure fatality rate is 50% and does not increased with age

nervous system

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice and heterozygotes

• latency to running bouncing seizures is 40% less than in wild-type mice or heterozygotes

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate is 50% and does not increased with age

abnormal nervous system electrophysiology ( J:131735 )

• neurons exhibit less depolarized sustained membrane potentials and reduced mean resting input resistance compared to wild-type neurons

• however, treatment with dendrotoxin abolishes the differences in neuron electrophysiology compared to wild-type neurons

• tityustoxin has no effect on neurons electrophysiology unlike in wild-type mice

abnormal action potential ( J:131735 )

• neurons exhibit a higher amplitude threshold than wild-type or heterozygous mice

• almost all neurons have low excitability compared to wild-type neurons

• however, all other action potentials and properties not dependent on potassium signaling are normal

impaired ability to fire action potentials ( J:131735 )

• neurons fire one action potentials when stimulated with 200-pA compared to 3 fired by wild-type mice

• neurons hypoexcitability does not change depending on the age of mice

abnormal channel response ( J:131735 )

• voltage-clamped inwards rectifier potassium current is larger than in wild-type neurons

growth/size/body

decreased body weight ( J:131735 )

• at P14, mice weigh 1 g less than wild-type and heterozygous mice

respiratory system

apnea ( J:131735 )

• mice likely die due to apnea during tonic extension

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice and heterozygotes

• latency to running bouncing seizures is 40% less than in wild-type mice or heterozygotes

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate is 50% and does not increased with age

Allelic Composition	Kcna2^tm1Tem/Kcna2^tm1Tem
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcna2^tm1Tem mutation (1 available); any Kcna2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:130097 )

• mice exhibit seizures resulting in death by P28

nervous system

seizures ( J:130097 )

• seizures are rare at P17

• mice exhibit seizures resulting in death by P28

• seizures occur during waking or during rapid eye movement sleep

• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity

abnormal brain wave pattern ( J:130097 )

• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity

• during non rapid eye movement sleep, mice exhibit higher EEG power in the low-frequency range (0.5 to 1.0 Hz) and lower EEG power in the 3.5 to 7 Hz frequency compared to wild-type mice

behavior/neurological

abnormal sleep pattern ( J:130097 )

• at P17, mice spend 23% less time in non-rapid eye movement (NREM) sleep, 21% more time in waking and a 10% decrease in rapid eye movement sleep (REM)compared to wild-type mice

• mice spend more time in waking during the light phase wild-type and heterozygous mice

• while the number of episodes of NREM are normal, the duration of NREM is reduced compared to in wild-type mice

• at P19, two mice exhibiting similar brain wave patterns as seen at P17 exhibit a 19% and 15% increase in waking time per 24 hours compared to wild-type and heterozygotes, respectively, and a 30% and 28% decrease in NREM sleep per 24 hours

seizures ( J:130097 )

• seizures are rare at P17

• mice exhibit seizures resulting in death by P28

• seizures occur during waking or during rapid eye movement sleep

• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity

growth/size/body

decreased body size ( J:130097 )

• while normal for the first 2 weeks of life, by P16 mice are smaller than wild-type

Allelic Composition	Kcna2^tm1Tem/Kcna2^tm1Tem
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcna2^tm1Tem mutation (1 available); any Kcna2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:131735 )

• mice survive 17+/-2 days

• observed seizure fatality rate does not increased with age

nervous system

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate does not increased with age

behavior/neurological

behavior/neurological phenotype ( J:131735 )

N	• unlike mice homozygous for a null allele of Kcna1, mice do not exhibit hyperexcitability following a cold swim

tonic seizures ( J:131735 )

• mice exhibit bursts of wild running and jumping followed by 5 to 10 seconds of full tonic extension similar to running bouncing seizures (RBS)

• observed seizure fatality rate does not increased with age

Allelic Composition	Kcna2^tm1Tem/Kcna2⁺
Genetic Background	C3Fe.129S7-Kcna2^tm1Tem

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcna2^tm1Tem mutation (1 available); any Kcna2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice but not as short as in homozygotes

impaired ability to fire action potentials ( J:131735 )

• neurons fire fewer action potentials than wild-type mice

• neurons hypoexcitability does not change depending on the age of mice

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:131735 )

• mice exhibit a shorter latency to seizure following treatment with flurothyl compared to wild-type mice but not as short as in homozygotes

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