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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdh2Gt(OST49160)Lex
gene trap OST149160, Lexicon Genetics
MGI:3525642
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex involves: 129S5/SvEvBrd MGI:3525861
cn2
Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N MGI:3580161


Genotype
MGI:3525861
hm1
Allelic
Composition
Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh2Gt(OST49160)Lex mutation (1 available); any Cdh2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryonic lethality as seen in homozygous null Cdh2 mice

cardiovascular system
• exhibited an identical phenotype to the Cdh2-null allele, Cdh2tm1Hyn
• at E9.5, had a malformed heart tube that consisted of rounded and dissociated myocytes surrounding the endocardium
• severe pericardial swelling at E9

homeostasis/metabolism
• severe pericardial swelling at E9

nervous system
• homozygotes showed a lack of brain development




Genotype
MGI:3580161
cn2
Allelic
Composition
Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic
Background
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cfTg(Myh6-cre/Esr1*)1Jmk mutation (2 available); any A1cf mutation (21 available)
Cdh2Gt(OST49160)Lex mutation (1 available); any Cdh2 mutation (19 available)
Cdh2tm1Glr mutation (1 available); any Cdh2 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants die about 2 months after tamoxifen treatment

cardiovascular system
• modest dilation of the atria after tamoxifen treatment
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
• after tamoxifen treatment intercalated disc structures are absent
• after tamoxifen treatment hearts appear elongated and flacid
• modest dilation of the ventricles after tamoxifen treatment
• modest dilation of the ventricles after tamoxifen treatment
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased
• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
• tachyarrhythmia is initiated by premature ventricular depolarization

muscle
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
• after tamoxifen treatment intercalated disc structures are absent
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory