Mouse Genome Informatics
hm1
    Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
involves: 129S5/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• embryonic lethality as seen in homozygous null Cdh2 mice

cardiovascular system
• exhibited an identical phenotype to the Cdh2-null allele, Cdh2tm1Hyn
• at E9.5, had a malformed heart tube that consisted of rounded and dissociated myocytes surrounding the endocardium
• severe pericardial swelling at E9

homeostasis/metabolism
• severe pericardial swelling at E9

nervous system
• homozygotes showed a lack of brain development


Mouse Genome Informatics
cn2
    Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
Tg(Myh6-cre/Esr1*)1Jmk/0

involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mutants die about 2 months after tamoxifen treatment

cardiovascular system
• modest dilation of the atria after tamoxifen treatment
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
• after tamoxifen treatment intercalated disc structures are absent
• after tamoxifen treatment hearts appear elongated and flacid
• modest dilation of the ventricles after tamoxifen treatment
• modest dilation of the ventricles after tamoxifen treatment
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased
• about 5 weeks after tamoxifen treatment, mutant heart rate is significantly reduced
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
• about 6 weeks after tamoxifen treatment, 2 mutants showed abrupt onset of ventricular tachyarrhythmia followed by sudden death
• tachyarrhythmia is initiated by premature ventricular depolarization

muscle
• after tamoxifen treatment enlarged hyperchromatic myocyte nuclei are seen
• after tamoxifen treatment intercalated disc structures and intercellular space are absent
• after tamoxifen treatment sarcomeres appear distorted and compressed with wider, less dense Z-lines
• after tamoxifen treatment intercalated disc structures are absent
• left ventricular end-diastolic and end-systolic volume in the cavity are increased and left ventricular ejection fraction is decreased