Mouse Genome Informatics
hm1
    Ambntm1Nid/Ambntm1Nid
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Defects in enamel formation of Ambntm1Nid/Ambntm1Nid mice

tumorigenesis
• dental epithelium derived soft tissue tumors in the buccal vestibule of the maxilla were seen in 6 out of 32 mutants with the earliest occurrence at 26 weeks of age

craniofacial
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue
• at P3 ameloblasts begin to detach from the matrix layer and lose cell polarity
• at P7 ameloblast cell polarity is completely lost, proliferation is increased, and the cells accumulate to form a multilayered structure
• at 3 weeks of age incisors appear chalky white with rounded tips
• the occlusal plane of the molar is flattened from attrition after eruption

skeleton
• the space between the tooth and alveolar bone is wider than normal and this space is invaded by calcified tissue

Mouse Models of Human Disease
OMIM IDRef(s)
Amelogenesis Imperfecta, Hypoplastic Type 104530 J:94844