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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park7tm1Cai
targeted mutation 1, Hubaibin Cai
MGI:3522482
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park7tm1Cai/Park7tm1Cai involves: 129X1/SvJ * C57BL/6 MGI:3833851


Genotype
MGI:3833851
hm1
Allelic
Composition
Park7tm1Cai/Park7tm1Cai
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7tm1Cai mutation (1 available); any Park7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice weigh less than controls starting around 1 year in age

behavior/neurological
• 16-month old mice have enhanced motor learning over 3 days with 62.3% increase in latency time to fall compared to just a 34.6% increase for wild-type controls
• mice at 16 months of age, but not 2 months of age, have a significant decrease in foregrip strength
• mice at 5 and 14 months of age have decreased activity
• two month old mice have defects in stride uniformity and hind base displacement
• defects are more severe in two year old mice
• two-year old mice have a mean decrease in stride length with a mean of 5.35 cm vs. 5.9 for controls
• dopamine treatment failed to increase stride length as it did for wild-type mice
• this defect in stride length is not observed in 2-month mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 7, Autosomal Recessive Early-Onset; PARK7 606324 J:141628





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory